After the vaccination campaigns of the 20th century, smallpox has become one of two infectious diseases that have been declared as completely eradicated (the other being rinderpest).

Disease trivia: Smallpox, the disease that scares humans
Disease trivia: Smallpox, the disease that scares humans

However, prior to vaccination, small pox claimed an estimated 500 million lives in just the 20th century alone.

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