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Trivia of clinical trials: John Hopkins Asthma Trial

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Ellen Roche, a technician at Johns Hopkins Hospital, volunteered to take part in an asthma trial for healthy individuals. The trial’s goal was to discover what mechanism kept healthy people from developing the symptoms of asthma, so the doctors induced a mild asthmatic reaction and then treated it with hexamethonium.

Trivia of clinical trials: John Hopkins Asthma Trial
Trivia of clinical trials: John Hopkins Asthma Trial

At first, inhaling this medicine simply caused Ms. Roche to develop a cough. But as time progressed, she was put on a ventilator as her lung tissue broke down and her kidneys began to fail. She died one month later, on June 2, 2001.Medical officials from the trial admit that the hexamethonium “was either solely responsible for the subject’s illness or played an important contributory role.” To make matters worse, participants learned after the trial that hexamethonium is not even an FDA-approved drug. This fact was not included in the consent form, so Johns Hopkins has been forced to take full responsibility for Roche’s death.

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Comments 3

  1. KbbfCland says:
    1 year ago

    Novartis is still optimistic about the drug and said it will continue to conduct two other phase 3 trials of fevipiprant (LUSTER 1 and LUSTER 2) to evaluate the efficacy of fevipiprant on acute attacks of moderate to severe asthma. These two late-stage asthma trials are the key , The results will be released in the first quarter of 2020. In addition, Novartis also reiterated its plan to submit a new drug application for fevipiprant in 2020.

    Novartis’ new asthma drug fevipiprant failed in Phase 3 clinical trials!

    Reply
  2. AbcfPasegoabe says:
    1 year ago

    For 30 consecutive years, it has been the university with the highest annual research funding in the United States (up to 1.5 billion US dollars per year)

    Reply
  3. AqcfPasegoabe says:
    2 years ago

    Do more experiments with these drugs! Danger!

    Reply

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