The drug Thalidomide was first manufactured in Germany, primarily for the purpose of treating respiratory infections. Today, many people know about this drug because of its adverse effects on pregnancy. Over 10,000 children born during the 1960s suffered serious impairments, such as missing limbs and cleft palates, as a result of this drug.

Clinical Trials: The Thalidomide Trials
Clinical Trials: The Thalidomide Trials

Unlike the other trials on the list, the eerie part of the thalidomide clinical trial was that everything went horribly right. During the patenting and approval phase, researchers tested the drug on animals but neglected to observe the effects on their offspring. Since it was impossible to die from an overdose of the medicine, it was deemed safe, and it hit the shelves in 1956.

It was not until 1961 that Australian doctor William McBride discovered the link between Thalidomide and the deformities. Until then, every clinical trial came to the conclusion that thalidomide was a safe over-the-counter medicine although10,000 people paid the price.

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